Understanding and fixing changes in the brain's blood barrier related to Alzheimer's disease
Identifying and Correcting Dementia-Associated Changes in the Blood-Brain Barrier
This study is looking at how changes in the brain's protective barrier might contribute to Alzheimer's disease, and it's trying to find ways to fix those changes to help keep the brain healthy, especially for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10611807 on NIH RePORTER |
What this research studies
This research focuses on the role of the brain's blood-brain barrier in Alzheimer's disease and aims to identify and correct changes that occur in the cells that make up this barrier. By studying various cell types involved in brain vasculature, the research seeks to restore the integrity of these cells, which is crucial for maintaining brain health. The approach involves both identifying the specific processes affected by Alzheimer's and developing strategies to improve brain vascular health, particularly in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing age-related cognitive decline.
Not a fit: Patients with early-stage Alzheimer's or those without any cognitive impairment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore brain function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in restoring brain vasculature in neurodegenerative diseases, indicating that this approach may be effective.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Rubin, Lee L — Harvard University
- Study coordinator: Rubin, Lee L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.