Understanding and eliminating HIV reservoirs in children
Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory
This study is looking at how HIV-1 affects infants and aims to find new treatments that could help children manage the virus better, so they might not need to take medicine for the rest of their lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11078299 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV-1 establishes and persists in children, particularly in infants. It aims to explore the unique characteristics of the pediatric immune system that affect the long-term presence of the virus. The project will test new therapies designed to eliminate HIV reservoirs and improve immune responses, potentially allowing children to control the virus without lifelong antiretroviral therapy. By conducting preclinical studies, the research seeks to pave the way for future human trials that could lead to a functional cure for pediatric HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents aged 0 to 21 years living with HIV.
Not a fit: Patients who are adults or those without HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a functional cure for HIV in children, reducing the need for lifelong medication.
How similar studies have performed: Previous research has shown promise in similar approaches targeting HIV reservoirs, indicating potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Persaud, Deborah — Johns Hopkins University
- Study coordinator: Persaud, Deborah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.