Understanding and diagnosing Alzheimer's Disease using advanced imaging techniques
Official title: Fluency from Flesh to Filament: Collation, Representation, and Analysis of Multi-Scale Neuroimaging data to Characterize and Diagnose Alzheimer's Disease
Funded at Johns Hopkins University · NIH-11117157 · Data updated 2026-11-12
This study is looking for better ways to diagnose Alzheimer's Disease by combining brain scans with tiny details about brain changes, so that patients can get more accurate diagnoses and personalized treatment options.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AG077736-03 |
| Project ID | NIH-11117157 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are experiencing cognitive decline or have been diagnosed with Alzheimer's Disease.
✕Less likely to help
Patients under the age of 65 or those without cognitive impairment may not receive benefit from this research.
What this research studies
This research aims to improve the diagnosis and understanding of Alzheimer's Disease (AD) by developing new methods to analyze neuroimaging data. It focuses on integrating microscopic pathology data with macroscopic MRI measures to identify in vivo biomarkers that can better characterize AD. By using advanced imaging techniques, the project seeks to correlate brain structure changes with the presence of tau and beta-amyloid pathology, which are critical in diagnosing AD. Patients may benefit from more accurate diagnoses and tailored treatment options based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment strategies for Alzheimer's Disease.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques to study Alzheimer's Disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Stouffer, Kaitlin — Johns Hopkins University
- Study coordinator: Stouffer, Kaitlin
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.