Understanding and controlling brain signals related to neuromodulators in awake children
Official title: Multiplexed Sensing and Control of Neuromodulators and Peptides in the Awake Brain
Funded at Beth Israel Deaconess Medical Center · NIH-10916477 · Data updated 2026-11-12
This study is looking at how certain brain chemicals change when kids are awake and alert, to help us understand how these changes might relate to brain disorders, with the hope of finding better ways to treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $216,125 |
| NIH project number | 5R21EY035436-02 |
| Project ID | NIH-10916477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who may be experiencing neurological or psychiatric disorders.
✕Less likely to help
Patients outside the age range of 0-11 years or those without neurological or psychiatric conditions may not benefit from this research.
What this research studies
This research investigates how various neuromodulators and chemical signals in the brain change dynamically during different states of arousal in awake children. By developing advanced techniques to simultaneously measure and manipulate these signals, the study aims to provide insights into how imbalances in these chemicals contribute to neurological disorders. The approach involves using innovative imaging methods to track these signals in real time, which could lead to better understanding and treatment of conditions affecting the brain. The ultimate goal is to enhance drug delivery strategies to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for neurological and psychiatric disorders in children by optimizing drug delivery and minimizing side effects.
How similar studies have gone: While the approach of simultaneously measuring multiple neuromodulatory signals is innovative, similar methodologies in neuroscience have shown promise in other contexts, indicating potential for success.
Where this research is happening
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Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Andermann, Mark L — Beth Israel Deaconess Medical Center
- Study coordinator: Andermann, Mark L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.