Understanding and classifying severe lung disease in premature infants
Official title: Multidimensional phenotype classification in grade 3 BPD
Funded at Children's Hosp of Philadelphia · NIH-11116920 · Data updated 2026-11-12
This study is looking at how to better understand and treat a serious lung condition called bronchopulmonary dysplasia (BPD) in premature babies by grouping them based on their specific needs, so we can improve their care and predict how they will do over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $838,922 |
| NIH project number | 5R01HL168066-03 |
| Project ID | NIH-11116920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants born prematurely who develop grade 3 bronchopulmonary dysplasia.
✕Less likely to help
Patients who do not have bronchopulmonary dysplasia or who are not born prematurely may not benefit from this research.
What this research studies
This research focuses on bronchopulmonary dysplasia (BPD), a serious lung condition affecting premature infants. It aims to improve the classification of grade 3 BPD by using a multidimensional approach to identify different patient subgroups based on their unique characteristics. By doing so, the research seeks to enhance the understanding of the disease's variability, improve treatment strategies, and predict patient outcomes more accurately. The study will involve analyzing clinical data and patient responses to better tailor interventions for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and improved health outcomes for infants suffering from severe lung disease.
How similar studies have gone: Previous research in similar chronic respiratory conditions has shown that multidimensional phenotyping can lead to significant advancements in treatment and patient outcomes.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Lingappan, Krithika — Children's Hosp of Philadelphia
- Study coordinator: Lingappan, Krithika
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.