Understanding and addressing the risks of using opioids and benzodiazepines together

Opioid/benzodiazepine polydrug abuse: Integrating research on mechanisms, treatment and policies

NIH-funded research Wayne State University · NIH-10685979

This study is looking at how using both opioids and benzodiazepines together can increase the risk of overdose and other health problems, and it's for anyone who is dealing with these substances to help find better ways to support their health.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionWayne State University NIH-funded
Lab location1 site (Detroit, United States)
Project IDNIH-10685979 on NIH RePORTER

What this research studies

This research investigates the complex issue of polydrug abuse involving opioids and benzodiazepines, focusing on the risks of overdose and disability. It aims to identify specific patient characteristics that contribute to these risks by analyzing data from behavioral health treatment records and conducting in-depth clinical assessments. The study employs a combination of population-level analysis and clinical evaluations to understand how these substances affect mental health and physical well-being. By integrating various methodologies, the research seeks to develop targeted interventions for those affected by this dual substance use.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals who are currently using both opioids and benzodiazepines and are experiencing related health issues.

Not a fit: Patients who are not using either opioids or benzodiazepines or those who do not have any associated health complications may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment strategies that reduce the risks associated with polydrug abuse, ultimately saving lives and enhancing patient well-being.

How similar studies have performed: Previous research has shown that addressing polydrug abuse through targeted interventions can lead to significant improvements in patient outcomes, suggesting that this approach has potential for success.

Where this research is happening

Detroit, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.