Understanding Amyloid Proteins in Alzheimer's Disease
Solid State NMR Studies of Amyloid Proteins
This work aims to understand the detailed structures of amyloid proteins, which are linked to conditions like Alzheimer's disease, to help find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11099914 on NIH RePORTER |
What this research studies
Our scientists are using advanced techniques called magic angle spinning (MAS) NMR and cryo-electron microscopy (cryoEM) to look closely at the structures of amyloid proteins. We are particularly interested in the Aβ proteins, which are known to form plaques in the brains of people with Alzheimer's disease. By mapping out these structures, we hope to learn how these proteins cause harm and how they interact with potential treatments, like the antibody Aducanumab. This detailed understanding is crucial for developing future therapies.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit individuals living with or at risk for Alzheimer's disease and other amyloid-related conditions in the future.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not receive benefit from participating in this basic science research.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into how amyloid proteins cause disease, paving the way for new diagnostic tools and more effective treatments for Alzheimer's and related conditions.
How similar studies have performed: While the specific structural details are novel, similar approaches using advanced imaging techniques have been successful in revealing insights into other disease-related proteins.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Griffin, Robert Guy — Massachusetts Institute of Technology
- Study coordinator: Griffin, Robert Guy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.