Understanding Alzheimer's Risk in Diverse Communities
Epigenetic Risk Factors for AD Age at Onset and Health Disparities: HABLE Epigenetics Study
['FUNDING_R01'] · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · NIH-11174255
This research looks at how changes in our DNA might affect when Alzheimer's disease starts and how it progresses in Mexican Americans and non-Hispanic whites.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NORTH TEXAS HLTH SCI CTR (nih funded) |
| Locations | 1 site (FORT WORTH, UNITED STATES) |
| Trial ID | NIH-11174255 on ClinicalTrials.gov |
What this research studies
We are exploring the connection between specific patterns in your DNA, called DNA methylation, and the presence and progression of Alzheimer's disease. By looking at these patterns in individuals from the ongoing HABLE group, we hope to uncover why Alzheimer's might affect people differently. This work builds on previous findings that linked DNA changes to memory decline and inflammation, especially in Mexican Americans. Our goal is to better understand these biological factors that contribute to Alzheimer's in diverse populations.
Who could benefit from this research
Good fit: This research is focused on understanding Alzheimer's disease in Mexican Americans and non-Hispanic whites, particularly those who have participated in the HABLE cohort.
Not a fit: Patients not part of the HABLE cohort or those with conditions other than Alzheimer's disease may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help us understand individual risk factors for Alzheimer's disease, potentially leading to earlier detection or more personalized prevention strategies.
How similar studies have performed: Prior work has identified specific DNA methylation patterns linked to cognitive decline, suggesting this approach has potential to uncover meaningful biological connections.
Where this research is happening
FORT WORTH, UNITED STATES
- UNIVERSITY OF NORTH TEXAS HLTH SCI CTR — FORT WORTH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARBER, ROBERT CLINTON — UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
- Study coordinator: BARBER, ROBERT CLINTON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease