Understanding Alzheimer's Disease using marmoset models
Project 3: Multi-modal phenotypic Characterization of marmoset models of Late Onset Alzheimer's Disease
This study is looking at marmoset monkeys to help us learn more about late-onset Alzheimer's Disease, so we can better understand how it develops and find new ways to treat it in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10899745 on NIH RePORTER |
What this research studies
This research investigates the use of marmoset monkeys as models for studying late-onset Alzheimer's Disease (AD). By examining these animals, researchers aim to uncover the genetic and biological factors that contribute to the development and progression of AD. The study will utilize a variety of methods to assess the animals' behavior, genetics, and pathology, providing insights that could lead to better understanding and treatment of the disease in humans. The goal is to create a more effective model that closely mimics human AD, which has been a challenge with existing animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for late-onset Alzheimer's Disease, particularly those with a family history of the condition.
Not a fit: Patients who are not at risk for Alzheimer's Disease or who have early-onset forms of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding Alzheimer's Disease and pave the way for new treatments.
How similar studies have performed: Other research has shown promise in using animal models to study Alzheimer's Disease, but the specific use of marmosets for this purpose is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Silva, Afonso C — University of Pittsburgh at Pittsburgh
- Study coordinator: Silva, Afonso C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.