Understanding Alzheimer's Disease through Biomarkers
Core F: Biomarker Core
This project helps us learn more about Alzheimer's disease by looking at specific markers in blood and spinal fluid from people with the condition.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11123108 on NIH RePORTER |
What this research studies
This core facility supports Alzheimer's disease research by analyzing important biological markers in patient samples. We measure levels of amyloid, tau, and markers of nerve damage in spinal fluid and blood, which are key indicators of Alzheimer's. We also look at inflammation, brain-supportive proteins, and metabolism-related factors in plasma, along with genetic material from mitochondria in blood and brain tissue. These detailed analyses help researchers understand the disease better and identify potential new ways to diagnose or treat it.
Who could benefit from this research
Good fit: Ideal candidates are individuals participating in the University of Kansas Alzheimer's Disease Research Center's cohort who provide blood and cerebrospinal fluid samples.
Not a fit: Patients not participating in the specific University of Kansas Alzheimer's Disease Research Center cohort or similar biomarker collection efforts would not directly benefit from this particular core's activities.
Why it matters
Potential benefit: If successful, this work could lead to better ways to diagnose Alzheimer's disease earlier, track its progression, and develop new treatments by identifying key biological targets.
How similar studies have performed: The methods for measuring amyloid, tau, and neurodegeneration biomarkers are well-established in Alzheimer's research, while the mitochondrial and metabolism biomarkers represent an innovative and unique area of focus.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Swerdlow, Russell H. — University of Kansas Medical Center
- Study coordinator: Swerdlow, Russell H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.