Understanding Alzheimer's Disease Proteins
Shared resource to develop tools and reagents to study structural polymorphisms in Abeta amyloid aggregates in AD
This work aims to create better ways to study the different forms of a protein called amyloid-beta, which is important in Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11088774 on NIH RePORTER |
What this research studies
Alzheimer's disease is a challenging condition affecting millions, and a key feature is the buildup of amyloid proteins in the brain. For many years, research on these amyloid proteins has sometimes led to confusing or conflicting results. This project focuses on developing standardized methods and materials to prepare and study these amyloid proteins, recognizing that they can take on many different shapes. By understanding these different shapes, we hope to clarify their role in the disease and improve future research.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit future patients diagnosed with Alzheimer's disease.
Not a fit: Patients not affected by Alzheimer's disease or those seeking immediate treatment options would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a clearer understanding of how amyloid proteins contribute to Alzheimer's disease, paving the way for more effective treatments.
How similar studies have performed: Advances in structural biology have shown that amyloid proteins can have distinct structures, but a lack of standardized methods has often led to conflicting results in past studies.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Glabe, Charles G. — University of California-Irvine
- Study coordinator: Glabe, Charles G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.