Understanding Alzheimer's disease in people with Down syndrome
Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
This study is looking at how Alzheimer's disease affects people with Down syndrome, aiming to understand the special genetic factors involved, so we can improve treatments and care for them in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10667549 on NIH RePORTER |
What this research studies
This research investigates how Alzheimer's disease (AD) develops in individuals with Down syndrome (DS), focusing on the unique genetic factors that may influence the disease's progression. By following a group of participants with DS, the study aims to identify the similarities and differences in the pathological changes associated with AD compared to the general population. The research employs a collaborative approach, utilizing advanced data analysis and biomarker identification to enhance our understanding of AD in this specific community. Ultimately, the findings could inform future clinical trials and treatment strategies tailored for individuals with DS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome who are 21 years or older.
Not a fit: Patients without Down syndrome or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding Alzheimer's disease through similar approaches, particularly in genetically at-risk populations.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Handen, Benjamin L — University of Pittsburgh at Pittsburgh
- Study coordinator: Handen, Benjamin L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.