Understanding Alzheimer's disease in diverse populations
Official title: HABS-HD - Project 1
Funded at University of North Texas Hlth Sci Ctr · NIH-10916346 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects different people, especially African Americans, to better understand the signs of the disease and how they change over time, so we can improve treatments for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas Hlth Sci Ctr NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $404,371 |
| NIH project number | 5U19AG078109-03 |
| Project ID | NIH-10916346 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include African American adults aged 21 and older who are at risk for or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are not African American or do not fall within the age range of 21 and older may not receive direct benefits from this research.
What this research studies
This research investigates the biological framework of Alzheimer's disease (AD) and its relevance to diverse populations, particularly focusing on African Americans who are disproportionately affected by AD and related dementias. The study aims to analyze the impact of various factors on the biomarkers of AD throughout adulthood, using a community-based approach to gather data. By including a diverse participant pool, the research seeks to enhance the understanding of how these biomarkers manifest and progress in different racial groups, which has been largely overlooked in previous studies. The findings could inform future clinical trials and therapeutic strategies tailored to these populations.
Why it matters
Potential benefit: If successful, this research could lead to more effective and inclusive treatments for Alzheimer's disease that consider the unique experiences and biological factors of diverse populations.
How similar studies have gone: While there has been significant research on Alzheimer's disease, this study's focus on diverse populations and the application of the AT(N) framework is relatively novel and aims to fill a critical gap in existing literature.
Where this research is happening
-
University of North Texas Hlth Sci Ctr
Fort Worth, United States Active
Researchers
- Principal investigator: O'bryant, Sid E — University of North Texas Hlth Sci Ctr
- Study coordinator: O'bryant, Sid E
Related research
Other NIH-funded projects on the same topics.
-
AIM-AHEAD Coordinating Center supports four core areas
This NIH grant funds a coordinating center to advance a multi-core effort that could benefit patients through streamlined research collaboration and data sharing.
-
The WNK1/OSR1 protein pathway's role in brain insulin use and age-related memory loss
This project will see if the WNK1/OSR1 protein pathway makes the aging brain use insulin and sugar less well and whether fixing that can help memory in Alzheimer’s-related conditions.
-
HBV prevention in community pharmacies: a first step in a low-resource setting
This pilot project tests whether hepatitis B screening and vaccination can be integrated into everyday community pharmacy services to reach more people.
-
Glutaredoxin and aging: how it affects cataracts and new treatment ideas
A research project explores how aging affects the lens of the eye and tests new ways to prevent or treat cataracts by studying antioxidant repair and inflammation.
-
Voltage-dependent potassium channels and tiny blood vessels in people
This NIH grant explores how special potassium channels control tiny blood vessels in adults, which could affect blood pressure and heart health.
-
Texas Center for Health Disparities: Building Leaders in Health Equity
Aims to grow and train more health disparities researchers at UNTHSC so they can better serve communities affected by AIDS, cancers, and cardiovascular diseases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.