Understanding Alzheimer's Disease in Adults with Down Syndrome
Core C: Clinical Core
This study is looking at how Alzheimer's disease develops in adults with Down syndrome and their siblings over five years, so we can better understand their health and memory changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10667571 on NIH RePORTER |
What this research studies
This research investigates how Alzheimer's disease progresses in adults with Down syndrome, who are at a high risk of developing dementia. The study will follow a group of 720 individuals, including adults with Down syndrome and their siblings, over five years, conducting evaluations every 16 months. Participants will undergo neuropsychological assessments, caregiver questionnaires, and physical examinations, along with genetic and biological sample collection. The goal is to create a comprehensive profile of health and cognitive abilities to better classify dementia status in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with Down syndrome aged 21 and older, as well as their sibling controls.
Not a fit: Patients without Down syndrome or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Alzheimer's disease in adults with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding Alzheimer's disease in similar populations, indicating that this approach has potential for success.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Handen, Benjamin L — University of Pittsburgh at Pittsburgh
- Study coordinator: Handen, Benjamin L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.