Understanding Alzheimer's Disease Genes in People and Fruit Flies
Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila Models
This project aims to understand the genetic causes of Alzheimer's disease by studying genes in both human data and fruit flies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11119018 on NIH RePORTER |
What this research studies
Alzheimer's disease is a complex condition influenced by many genes, and this project seeks to identify which specific genes and genetic changes contribute to its development. We will combine information from human genetic studies, including brain tissue data, to pinpoint important genes and variations. Then, we will use high-throughput screening in fruit flies to test how these genes work and how they might lead to the disease. The goal is to speed up our understanding of Alzheimer's genetics and identify new targets for treatments.
Who could benefit from this research
Good fit: This foundational genetic work does not directly recruit patients but uses existing human genetic data and samples from individuals with Alzheimer's disease and related dementias.
Not a fit: Patients not diagnosed with Alzheimer's disease or related dementias would not directly benefit from the findings of this specific genetic research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the genetic causes of Alzheimer's disease, potentially identifying new targets for future treatments or prevention strategies.
How similar studies have performed: Previous genetic studies have made significant progress in identifying genes linked to Alzheimer's, and this project builds upon those successes using advanced genomic and experimental techniques.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Shulman, Joshua M — Baylor College of Medicine
- Study coordinator: Shulman, Joshua M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.