Understanding Alzheimer's Disease Biomarkers at the University of Kentucky
Core F: University of Kentucky Alzheimer's Disease Core Center
This project aims to find different biological signs in people to better understand how Alzheimer's disease and other dementias develop.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11123391 on NIH RePORTER |
What this research studies
This core focuses on identifying various biological markers (biomarkers) that show how different underlying issues contribute to memory decline. We collect blood and spinal fluid samples to look for signs of Alzheimer's, blood vessel problems, and inflammation. We also use advanced MRI scans to see changes in the brain and explore wearable devices to track sleep and activity patterns. This multi-faceted approach helps us gain new insights into complex dementias, especially those with multiple causes. Our goal is to characterize individuals from a cognitively normal state through their cognitive transitions.
Who could benefit from this research
Good fit: Individuals experiencing cognitive changes or those at risk for Alzheimer's disease and other dementias, including those who are cognitively normal but part of a cohort, would be ideal candidates.
Not a fit: Patients not interested in providing biological samples or undergoing imaging may not directly benefit from participation in this specific biomarker collection effort.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more accurate ways to identify Alzheimer's disease and related dementias, potentially guiding future treatments.
How similar studies have performed: The use of multimodal biomarkers is a growing area in dementia research, with many studies showing promise in identifying disease progression and underlying pathologies.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Gold, Brian Timothy — University of Kentucky
- Study coordinator: Gold, Brian Timothy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.