Understanding Alzheimer's Disease and Related Dementias through Patient Data
Official title: Multi-morbidity 3-City Alzheimer's Disease EHR Study (M3AD Study)
Funded at Columbia University Health Sciences · NIH-11172976 · Data updated 2026-11-12
This study is looking at how different health issues affect people with Alzheimer's and related dementias, using data from many patients to find better ways to predict risks and create personalized care plans just for you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $5,387,161 |
| NIH project number | 1R56AG082167-01A1 |
| Project ID | NIH-11172976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or related dementias, particularly those from diverse ethnic backgrounds.
✕Less likely to help
Patients with early-stage cognitive impairment or those without a diagnosis of Alzheimer's Disease or related dementias may not benefit from this research.
What this research studies
This research focuses on patients affected by Alzheimer's Disease (AD) and Related Dementia (AD/ADRD) by utilizing large electronic health records (EHRs) from multiple cities to improve risk prediction and personalized prevention strategies. The study aims to recognize the interconnectedness of chronic diseases and how they influence each other, thereby enhancing clinical outcomes for patients. By analyzing diverse patient data, including social factors, the research seeks to tailor management approaches to the unique complexities of each individual.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for patients with Alzheimer's Disease and related dementias.
How similar studies have gone: Previous research utilizing electronic health records to study chronic diseases has shown promise, indicating that this approach could yield valuable insights into Alzheimer's Disease management.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Desvarieux, Moise — Columbia University Health Sciences
- Study coordinator: Desvarieux, Moise
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.