Understanding Alzheimer's disease and brain aging through autopsy research
Core D: University of Kentucky Alzheimer's Disease Core Center
This study is looking at how Alzheimer's disease affects the brain by examining tissue from people who have passed away, helping us understand the disease better and find new ways to diagnose and treat it.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10880729 on NIH RePORTER |
What this research studies
This research focuses on investigating the effects of Alzheimer's disease and normal brain aging by performing autopsies on individuals who have been closely monitored over time. The Rapid Autopsy Team conducts these autopsies shortly after death to collect brain tissue and other biological samples, which are then analyzed for various pathological features associated with dementia. By maintaining a high autopsy rate and a comprehensive tissue bank, the research aims to provide valuable insights into the progression of Alzheimer's and related disorders, ultimately aiding in the development of better diagnostic and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, mild cognitive impairment, or other dementing disorders who are willing to participate in post-mortem studies.
Not a fit: Patients who are not diagnosed with any form of dementia or cognitive impairment may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease and other dementias.
How similar studies have performed: Previous research has shown success in using autopsy-derived data to enhance understanding of Alzheimer's disease pathology, making this approach well-established.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Nelson, Peter T. — University of Kentucky
- Study coordinator: Nelson, Peter T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.