Understanding aging through specialized immune cells
Deconstructing aging with senolytic CAR T cells
['FUNDING_OTHER'] · COLD SPRING HARBOR LABORATORY · NIH-10918338
This study is looking at how special immune cells called CAR T cells can help get rid of old, damaged cells that make us age faster, with the hope of improving health for older adults.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLD SPRING HARBOR LABORATORY (nih funded) |
| Locations | 1 site (COLD SPRING HARBOR, UNITED STATES) |
| Trial ID | NIH-10918338 on ClinicalTrials.gov |
What this research studies
This research investigates how certain immune cells, known as CAR T cells, can be used to target and eliminate senescent cells that contribute to aging and age-related diseases. By identifying specific markers on these senescent cells, the researchers aim to develop a method to isolate and characterize them more effectively. The approach involves harnessing the unique properties of CAR T cells to potentially rejuvenate tissues and improve health outcomes in older individuals. Patients may be involved in trials that explore the effectiveness of this innovative therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or those with conditions linked to cellular senescence.
Not a fit: Patients who are not elderly or do not have age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down the aging process and improve health in older adults.
How similar studies have performed: Other research has shown promise in using CAR T cell therapies for various conditions, suggesting potential success in this novel application for aging.
Where this research is happening
COLD SPRING HARBOR, UNITED STATES
- COLD SPRING HARBOR LABORATORY — COLD SPRING HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AMOR VEGAS, CORINA — COLD SPRING HARBOR LABORATORY
- Study coordinator: AMOR VEGAS, CORINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.