Understanding aging symptoms in mothers who carry a genetic mutation.
Aging Symptom Trajectories in Mother Carriers of the FMR1 Premutation
This study looks at how aging affects mothers with a specific genetic condition called the FMR1 premutation, comparing their experiences with those of mothers without it, to better understand their mental health and social interactions as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11083633 on NIH RePORTER |
What this research studies
This research investigates how mothers who carry the FMR1 premutation experience aging symptoms compared to those without the mutation. It focuses on understanding the long-term effects of this genetic condition on mental health, social interactions, and executive functioning as these mothers age. By collecting longitudinal data, the study aims to identify patterns of decline and the biological factors that may contribute to these changes. This information could help improve clinical management and support for these mothers and their families.
Who could benefit from this research
Good fit: Ideal candidates for participation are mothers who are carriers of the FMR1 premutation, particularly those experiencing symptoms related to aging.
Not a fit: Patients who do not carry the FMR1 premutation or are not mothers may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of aging-related health issues in mothers carrying the FMR1 premutation.
How similar studies have performed: Previous research has indicated significant health impacts associated with the FMR1 premutation, but this specific longitudinal approach is relatively novel.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Klusek, Jessica — University of South Carolina at Columbia
- Study coordinator: Klusek, Jessica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.