Understanding Aging Cells in Parkinson's Disease
Molecular Assessment of Cause and Consequence of Cellular Senescence in Diverse Midbrain Cell Types in Parkinson's Disease
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11111380
This research explores how aging cells in the brain contribute to Parkinson's disease, hoping to find new ways to help people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11111380 on ClinicalTrials.gov |
What this research studies
We know that Parkinson's disease is a common condition that affects older adults, but we don't fully understand why it happens. Our team has found that certain brain cells in people with Parkinson's can enter a state of 'senescence,' meaning they age and stop working properly. These aging cells can also release signals that cause inflammation and harm other healthy brain cells. This project aims to uncover what triggers these cells to age, how they spread their harmful effects, and how they contribute to the loss of important brain cells in Parkinson's disease.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but future studies based on this work may seek individuals with Parkinson's disease or those at risk.
Not a fit: Patients not affected by Parkinson's disease or related neurodegenerative conditions would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target these aging cells, potentially slowing down or preventing the progression of Parkinson's disease.
How similar studies have performed: The concept of cellular senescence is gaining traction in age-related diseases, and some early studies in other conditions have shown promise in targeting senescent cells.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIESSLAND, MARKUS — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: RIESSLAND, MARKUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.