Understanding Aging Cells in Different Types of Alzheimer's Disease
Identification and Characterization of Senescent Cells in Molecular Subtypes of Alzheimer's Disease
This project aims to understand how aging cells contribute to different forms of Alzheimer's disease to find new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11182528 on NIH RePORTER |
What this research studies
Alzheimer's disease can affect people in many different ways, suggesting it might be several diseases rather than just one. We know that certain "aging" cells, called senescent cells, play a role in many age-related conditions, including Alzheimer's. This work will look closely at these aging cells in the different molecular types of Alzheimer's to see how they behave. Our goal is to uncover new targets for treatments that could remove these cells and potentially slow or stop the disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical trials based on these findings would seek individuals diagnosed with Alzheimer's disease.
Not a fit: Patients whose condition is not related to the specific molecular subtypes or senescent cell mechanisms being studied may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could lead to new medications that specifically target harmful aging cells in the brain, offering more effective treatments for people with Alzheimer's disease.
How similar studies have performed: The idea of targeting senescent cells (senolytics) has shown promise in improving various age-associated conditions, making this a promising area for Alzheimer's research.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Zhang, Bin — Icahn School of Medicine at Mount Sinai
- Study coordinator: Zhang, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.