Understanding aging cells in different types of Alzheimer's disease
Official title: Identification and Characterization of Senescent Cells in Molecular Subtypes of Alzheimer's Disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-10990629 · Data updated 2026-11-12
This study is looking at how aging cells in the brain might play a role in different types of Alzheimer's disease, with the hope of finding new ways to treat the condition that are better suited to each person's unique situation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $842,114 |
| NIH project number | 1R01AG085182-01A1 |
| Project ID | NIH-10990629 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those who may exhibit different molecular subtypes.
✕Less likely to help
Patients with other forms of dementia not related to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how aging cells, known as senescent cells, contribute to the different molecular types of Alzheimer's disease (AD). By examining these cells, the study aims to uncover unique characteristics and mechanisms that may lead to new treatment targets. The research employs advanced techniques like ATAC sequencing and artificial intelligence to analyze brain samples and identify potential therapeutic strategies. Patients may benefit from insights that could lead to more effective treatments tailored to their specific subtype of Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in targeting senescent cells for age-related conditions, suggesting potential for success in this novel approach for Alzheimer's disease.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Zhang, Bin — Icahn School of Medicine at Mount Sinai
- Study coordinator: Zhang, Bin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.