Understanding aggressive prostate cancer pathology
Systems analysis of aggressive prostate cancer pathology
This study is looking at the genetic changes that make prostate cancer more aggressive, using tissue samples and special mouse models to find out what drives the disease, with the hope of discovering new treatments that can help patients facing tough cases of prostate cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10681271 on NIH RePORTER |
What this research studies
This research investigates the underlying genetic changes that lead to aggressive forms of prostate cancer. By analyzing tissue samples and using advanced mouse models, the team aims to identify specific molecular subtypes that drive the disease's progression. The study employs innovative techniques to genetically modify prostate stem cells and observe how these changes affect cancer development. Ultimately, the goal is to find targeted therapies that can improve outcomes for patients with aggressive prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with localized prostate cancer who are at risk of developing aggressive disease.
Not a fit: Patients with non-aggressive prostate cancer or those who have already progressed to advanced metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with aggressive prostate cancer, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in using genetic modeling to understand cancer pathology, indicating that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Costello, James Christopher — University of Colorado Denver
- Study coordinator: Costello, James Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.