Understanding aggressive prostate cancer in African American veterans
Official title: Investigating the mechanisms of aggressive prostate cancer in African American Veterans
Funded at Veterans Affairs Med Ctr San Francisco · NIH-11043423 · Data updated 2026-11-12
This study is looking into why African American men, especially veterans, tend to have more aggressive prostate cancer by examining their cancer samples and creating new cell models to better understand the genetic differences and how they affect the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX002444-03 |
| Project ID | NIH-11043423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American veterans diagnosed with prostate cancer.
✕Less likely to help
Patients who are not African American or who do not have prostate cancer may not benefit from this research.
What this research studies
This research investigates why African American men, particularly veterans, experience higher rates of aggressive prostate cancer. The team will analyze genetic differences in prostate cancer samples from 100 African American veterans to identify unique genomic alterations. They will also study how these alterations affect cancer biology by creating new cell models and examining the behavior of prostate cells at a molecular level. This approach aims to uncover the underlying mechanisms that contribute to the severity of prostate cancer in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for aggressive prostate cancer in African American men.
How similar studies have gone: Other research has shown that investigating genetic differences in cancer can lead to significant advancements in treatment, making this approach promising.
Where this research is happening
-
Veterans Affairs Med Ctr San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Huang, Franklin W — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Huang, Franklin W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.