Understanding age-related changes in blood cell formation and their health impacts
The Biological Consequences of Age-related Clonal Hematopoiesis
This study is looking at a condition called clonal hematopoiesis of indeterminate potential (CHIP) in people aged 85 and older to see how it might lead to serious health problems like leukemia and heart disease, with the goal of finding better ways to manage and understand these risks for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11032732 on NIH RePORTER |
What this research studies
This research investigates clonal hematopoiesis of indeterminate potential (CHIP), a condition where mutations occur in blood-forming cells, particularly in individuals aged 85 and older. The study aims to understand how these mutations can lead to serious health issues like leukemia and cardiovascular diseases. By following a large group of older adults with CHIP, researchers hope to uncover the mechanisms behind its progression and its effects on overall health. This could help in developing better risk assessment and management strategies for older patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 85 and older who have been diagnosed with clonal hematopoiesis.
Not a fit: Patients younger than 85 or those without clonal hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of age-related blood disorders, potentially reducing the risk of serious complications for older adults.
How similar studies have performed: Previous research has shown that understanding the mechanisms of CHIP can lead to significant insights into age-related health issues, indicating potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Gondek, Lukasz Pawel — Johns Hopkins University
- Study coordinator: Gondek, Lukasz Pawel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.