Understanding Adrenal Gland Structures in Health and Disease
Rosettes in Adrenal Development, Maintenance and Disease
This work explores how tiny structures in the adrenal glands, called rosettes, form and change, and how they might lead to conditions like high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11142969 on NIH RePORTER |
What this research studies
Our adrenal glands constantly adjust to our body's needs, but we don't fully understand how. This work looks at special cell clusters, called rosettes, in the adrenal glands that are important for producing hormones like aldosterone. We are learning how these rosettes develop and change, and how problems with them might contribute to diseases such as primary aldosteronism, a common cause of high blood pressure. By studying these processes, we hope to uncover new ways to help people with adrenal gland conditions.
Who could benefit from this research
Good fit: Patients with primary aldosteronism or other adrenal gland disorders might eventually benefit from this foundational understanding.
Not a fit: Patients with conditions unrelated to adrenal gland function or aldosterone production would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and treat primary aldosteronism and related high blood pressure conditions.
How similar studies have performed: This work builds upon prior findings about adrenal cortex remodeling and introduces novel insights into the role of rosettes and specific genetic factors in disease.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Breault, David T — Boston Children's Hospital
- Study coordinator: Breault, David T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.