Understanding Adolescent Idiopathic Scoliosis and Spine Development
Forward and Reverse Genetic Studies of AIS and Spine Development in Zebrafish
['FUNDING_P01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11121822
This research explores the genetic causes of adolescent idiopathic scoliosis, a common spine condition, to help us better understand why it happens.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11121822 on ClinicalTrials.gov |
What this research studies
Adolescent idiopathic scoliosis (AIS) is a common spine condition in children, often requiring bracing or surgery in severe cases. We are working to uncover the genetic reasons behind AIS by studying spine development in zebrafish, a small fish model. Our team has already identified several genes linked to spine issues in zebrafish, and we are continuing to look for more. This work helps us understand how genes affect spine health and what goes wrong in AIS.
Who could benefit from this research
Good fit: This foundational genetic research is relevant for children and adolescents affected by idiopathic scoliosis, as it aims to uncover the underlying biological mechanisms of their condition.
Not a fit: Patients not affected by adolescent idiopathic scoliosis or related spine development disorders would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the genetic causes of scoliosis, potentially paving the way for new ways to prevent or treat the condition.
How similar studies have performed: Previous work by this collaborative team has already identified numerous genes involved in spine development and scoliosis using similar genetic approaches in zebrafish.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOLNICAKREZEL, LILIANNA — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: SOLNICAKREZEL, LILIANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.