Understanding Adenomyosis at the Cellular Level to Find New Treatments
Single cell analytics and drug discovery at the endometrial-myometrial junction in symptomatic adenomyosis
This work aims to understand adenomyosis, a common uterine condition, by looking closely at individual cells to find new ways to help women with symptoms.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11141913 on NIH RePORTER |
What this research studies
Adenomyosis is a common uterine condition where cells from the uterine lining grow into the muscular wall, causing severe pain, heavy bleeding, and fertility issues. Current treatments often have limitations, and a hysterectomy is the only cure, which is not an option for those wishing to conceive. This project uses advanced techniques to examine these cells at a very detailed level, hoping to uncover new insights into how the disease develops. By understanding these cellular changes, we can identify specific targets for new medications. The ultimate goal is to develop more effective and targeted treatments that can reduce symptoms and improve the quality of life for affected women.
Who could benefit from this research
Good fit: This foundational research is for women diagnosed with symptomatic adenomyosis who are seeking better treatment options beyond current therapies.
Not a fit: Patients without adenomyosis or those whose symptoms are well-managed by existing treatments may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new, targeted medications that effectively reduce pain and bleeding associated with adenomyosis, offering alternatives to surgery.
How similar studies have performed: While single-cell analysis is a cutting-edge approach, previous bulk tissue analyses have provided initial clues, suggesting this detailed method holds promise for drug discovery.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Giudice, Linda C — University of California, San Francisco
- Study coordinator: Giudice, Linda C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.