Understanding Acetylation Reactions in Our Bodies
Molecular Mechanisms, Pathways and Inhibition of Acetyl-Transfer Reactions
This research explores how tiny chemical changes called acetylation happen in our cells, which are vital for life and health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11177622 on NIH RePORTER |
What this research studies
Our bodies rely on chemical changes called acetylation, which are like tiny switches that turn on or off important processes in our cells. These changes affect proteins and other molecules, helping our bodies respond to different signals and build essential components like fats and cholesterol. This project aims to understand exactly how the enzymes responsible for these acetylation reactions work and how they are controlled. By learning more about these fundamental processes, we hope to uncover why problems with acetylation can lead to health issues.
Who could benefit from this research
Good fit: This foundational laboratory research does not involve direct patient participation, but future studies building on this work may seek patients with conditions related to cellular acetylation.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge that helps scientists develop new ways to address diseases linked to problems with acetylation.
How similar studies have performed: Many studies have explored aspects of acetylation, and this research builds upon existing knowledge to delve deeper into the precise molecular details of these essential reactions.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Marmorstein, Ronen — University of Pennsylvania
- Study coordinator: Marmorstein, Ronen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.