Understanding accelerated heart aging in young adult cancer survivors
Role of disparities and aging biomarkers in accelerated cardiac aging among adolescent and young adult cancer survivors
This work aims to understand why some adolescent and young adult cancer survivors experience heart aging faster than expected and to find ways to identify those most at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11136403 on NIH RePORTER |
What this research studies
Many young people treated for cancer receive therapies that can affect their heart health later in life. We've noticed that the hearts of some adolescent and young adult cancer survivors appear to function like those of much older individuals. This project will look at 1,200 cancer survivors to understand how often this accelerated heart aging happens and if there are differences among various patient groups. We also want to find specific biological signs that can help predict who might develop heart problems after cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be adolescent and young adult cancer survivors who have received cardiotoxic treatments.
Not a fit: Patients who have not had cancer or who are outside the adolescent and young adult age range may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help identify young cancer survivors at high risk for heart problems, allowing for earlier monitoring and potentially new ways to protect their heart health.
How similar studies have performed: While preliminary data suggests this phenomenon, the incidence and predictors of accelerated cardiac aging in this specific population are not well understood, making this a novel area of focus.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Hildebrandt, Michelle a T — University of Tx Md Anderson Can Ctr
- Study coordinator: Hildebrandt, Michelle a T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.