Understanding a unique type of cell death in worms and its implications for mammals
Linker cell death regulation in C. elegans
This study is looking at a unique way that cells can die, which is different from the usual process, using tiny worms called C. elegans, to help us learn more about how this might affect development and diseases like Alzheimer's in humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10896007 on NIH RePORTER |
What this research studies
This research investigates a specific type of cell death that does not follow the typical apoptotic pathway, using the model organism C. elegans. The researchers aim to uncover the molecular mechanisms behind this non-apoptotic cell death, which may play crucial roles in development and disease in mammals. By studying the linker cell in C. elegans, they are exploring how this process operates independently of known apoptotic genes. The findings could provide insights into alternative cell death pathways that are important for understanding various diseases, including neurodegenerative conditions.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with neurodegenerative diseases or conditions related to abnormal cell death.
Not a fit: Patients with conditions unrelated to cell death mechanisms or those under 21 years old may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases characterized by abnormal cell death, such as neurodegenerative disorders.
How similar studies have performed: While the specific approach of investigating non-apoptotic cell death in this context is novel, similar research has shown promise in understanding cell death mechanisms in other models.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Shaham, Shai — Rockefeller University
- Study coordinator: Shaham, Shai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.