Understanding a special protein, Pol II(G), and its role in development and cancer
Mechanistic studies of transcription initiation and elongation functions of an RNA polymerase II variant, Pol II(G), that is implicated in development and cancer
This research explores how a specific protein called Pol II(G) works in our cells, especially its connection to normal development and diseases like breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11118912 on NIH RePORTER |
What this research studies
Our bodies rely on precise control of how genes are turned on and off, a process called transcription, which is often disrupted in diseases like cancer. A key player in this process is RNA polymerase II (Pol II), and this project focuses on a unique version of it, Pol II(G), which includes an extra component called Gdown1. We are learning how Pol II(G) helps start and continue the gene-reading process, and how it influences cell growth and metabolism. Understanding these basic mechanisms could reveal new ways that cancer cells grow and survive.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but its findings could eventually inform future treatments for individuals with breast cancer or other cancers where Pol II(G) plays a role.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research, as it focuses on understanding disease mechanisms rather than clinical intervention.
Why it matters
Potential benefit: If successful, this work could uncover fundamental mechanisms of cancer development, potentially leading to new targets for future cancer treatments, especially for breast cancer.
How similar studies have performed: The Pol II(G) variant and its specific functions are a relatively new area of focus, making this research novel in its detailed mechanistic approach to its role in development and cancer.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Roeder, Robert G — Rockefeller University
- Study coordinator: Roeder, Robert G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.