Understanding a Protein's Role in Blood Vessel Growth for Tooth Repair
Role of DMP1 Mediated Paracrine Signaling in Vasculogenesis
This project aims to discover how a special protein helps blood vessels form, which is crucial for repairing damaged teeth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11121899 on NIH RePORTER |
What this research studies
When you need to repair or regenerate a damaged tooth, it's really important for new blood vessels to grow quickly. These blood vessels bring oxygen and nutrients, and help clear away waste, which is essential for proper healing. Our team is looking at a protein called DMP1, which is known to be important for bone and tooth development. We believe DMP1 plays a role in helping adult stem cells transform into the cells that build new blood vessels, ultimately improving how teeth heal.
Who could benefit from this research
Good fit: Patients who have experienced tooth damage or require complex dental repair procedures might eventually benefit from this research.
Not a fit: Patients without conditions requiring dentin or pulp regeneration would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to regenerate damaged tooth tissue and improve dental repair procedures.
How similar studies have performed: The researchers have previously identified DMP1's role in mineralization and as a signaling molecule, and have observed its effect on pro-angiogenic factors, suggesting a foundation for this new hypothesis.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: George, Anne — University of Illinois at Chicago
- Study coordinator: George, Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.