Understanding a Protein's Role in Asthma and Airway Muscles
E3 ubiquitin ligase RNF145 in airway smooth muscle functions and in asthma
This project explores how a specific protein called RNF145 contributes to changes in the airways of people with asthma, hoping to find new ways to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11303760 on NIH RePORTER |
What this research studies
Asthma can cause changes in the cells lining our airways, including the smooth muscle cells. This project focuses on a specific protein, RNF145, which appears to be more active in the airway muscle cells of people with asthma. Early findings suggest that reducing the activity of RNF145 might help slow down or even reverse some of the harmful changes in these cells, such as excessive growth and scarring. By studying RNF145 in both human airway cells and animal models, researchers aim to uncover new ways to manage asthma symptoms and improve lung health.
Who could benefit from this research
Good fit: This foundational research is relevant to adult patients living with asthma, particularly those experiencing airway remodeling or severe symptoms.
Not a fit: Patients seeking immediate new treatments may not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new medications that specifically target the RNF145 protein to better control asthma symptoms and prevent airway remodeling.
How similar studies have performed: This project builds upon promising preliminary data from the research team, exploring a specific protein pathway that is a relatively new target in asthma.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Sharma, Pawan — Temple Univ of the Commonwealth
- Study coordinator: Sharma, Pawan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.