Understanding a Protein's Role in Alzheimer's Disease
Regulation of CHCHD6 in Alzheimer's disease
This research explores how a specific protein called CHCHD6 might contribute to Alzheimer's disease by affecting brain cell energy and how a key Alzheimer's protein is processed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11291353 on NIH RePORTER |
What this research studies
Alzheimer's disease is the most common form of dementia, and a key part of its development involves how a protein called amyloid-beta is processed in the brain. We know that the energy-producing parts of our cells, called mitochondria, don't work well in Alzheimer's, and this problem is linked to how amyloid-beta forms. This project focuses on a specific protein within mitochondria, CHCHD6, which has been found in lower amounts in the brains of Alzheimer's patients. By understanding how CHCHD6 works and how it's regulated, we aim to uncover new ways to prevent or treat Alzheimer's disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications may benefit individuals with Alzheimer's disease.
Not a fit: Patients not currently experiencing Alzheimer's disease symptoms would not directly benefit from this specific basic science project.
Why it matters
Potential benefit: If successful, this work could identify new targets for developing treatments that slow or stop the progression of Alzheimer's disease.
How similar studies have performed: This work builds on recent findings that suggest a specific protein is reduced in Alzheimer's patients, aiming to uncover the detailed mechanisms behind this observation.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Qi, Xin — Case Western Reserve University
- Study coordinator: Qi, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.