Understanding a protein that helps tuberculosis bacteria survive
Official title: A novel protein export chaperone of Mycobacterium tuberculosis
Funded at Colorado State University · NIH-11001046 · Data updated 2026-11-12
This study is looking at a special protein in the tuberculosis bacteria that helps it grow and cause illness, with the goal of finding new ways to treat TB and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $508,167 |
| NIH project number | 7R01AI149727-05 |
| Project ID | NIH-11001046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with tuberculosis or those at high risk of TB infection.
✕Less likely to help
Patients with non-tuberculosis related infections or conditions will likely not benefit from this research.
What this research studies
This research investigates a specific protein export chaperone called SatS in Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By exploring how SatS functions in exporting proteins critical for the bacteria's growth and virulence, the research aims to uncover new strategies to combat tuberculosis. The study will involve detailed analysis of SatS's mechanisms, its structure, and the proteins it interacts with, which could lead to innovative treatments for TB. Patients may benefit from this research as it could lead to the development of new anti-TB therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively combat tuberculosis.
How similar studies have gone: While the specific approach of targeting the SatS protein is novel, similar research has shown promise in understanding bacterial mechanisms and developing new treatments.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Braunstein, Miriam S. — Colorado State University
- Study coordinator: Braunstein, Miriam S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.