Understanding a protein complex involved in gene control and diseases like cancer
Structural insights into the Argonaute-containing CDK8 complex
This research explores how a specific protein complex, called Cdk8, controls gene activity in our bodies, which is important because changes in this complex are connected to various cancers and brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11145844 on NIH RePORTER |
What this research studies
Our bodies have a complex system called Mediator that helps turn genes on and off, and a key part of this system is the Cdk8 kinase module (CKM). This CKM is made of several proteins, and when they are faulty or too abundant, they are linked to conditions like breast and colorectal cancers, as well as certain brain development issues. We want to uncover the detailed structure of this CKM and understand exactly how it works to regulate gene expression. By learning how Cdk8 becomes active and interacts with other molecules, we hope to reveal the fundamental ways it contributes to health and disease.
Who could benefit from this research
Good fit: This basic science research does not involve direct patient participation but aims to benefit patients with cancers and neurodevelopmental disorders in the future.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find benefit from this foundational laboratory research.
Why it matters
Potential benefit: If successful, this foundational understanding could lead to the development of new treatments that target the Cdk8 complex for various cancers and neurodevelopmental disorders.
How similar studies have performed: While the Cdk8 complex is known to be linked to human diseases, its fundamental mechanisms in gene regulation are still not well understood, making this a novel and important area of investigation.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Tsai, Kuang-Lei — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Tsai, Kuang-Lei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.