Understanding a Protein Called RHAMM B in Pancreatic Cancer Spread
Receptor for hyaluronan-mediated motility isoform B (RHAMM B) in Pancreatic Cancer Metastasis
This work explores how a specific protein, RHAMM B, helps pancreatic cancer spread and aims to find new ways to stop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11146433 on NIH RePORTER |
What this research studies
Pancreatic cancer is often deadly because it spreads quickly, and current treatments are not always enough. Our team found that a protein called RHAMM B is often increased in pancreatic cancer and might be linked to poorer outcomes. We are looking into how RHAMM B helps cancer cells move and invade other tissues, and how it affects the way these cells store fats. By understanding this process, we hope to discover new targets for medicines that could prevent the cancer from spreading.
Who could benefit from this research
Good fit: This foundational laboratory work is not directly recruiting patients, but future clinical trials based on these findings would likely seek patients with pancreatic cancer, especially those at risk for metastasis.
Not a fit: Patients without pancreatic cancer or those whose cancer does not involve the RHAMM B protein may not directly benefit from this specific research direction.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically target RHAMM B to prevent pancreatic cancer from spreading, potentially improving patient survival.
How similar studies have performed: Our team was the first to identify RHAMM B's role in pancreatic neuroendocrine tumors, and this work extends that novel finding to the more common pancreatic ductal adenocarcinoma.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Du, Yi-Chieh Nancy — Weill Medical Coll of Cornell Univ
- Study coordinator: Du, Yi-Chieh Nancy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.