Understanding a protein called CCN3 for healthy blood vessels
Matricellular protein CCN3 in vascular homeostasis
This research explores how a protein named CCN3 helps keep our blood vessels healthy, especially in conditions like aortic aneurysm.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11109476 on NIH RePORTER |
What this research studies
Our bodies rely on healthy blood vessels, and this project focuses on the inner lining of these vessels, called the endothelium, which is crucial for preventing diseases. We are learning that problems with these endothelial cells can lead to serious conditions like thoracic aortic aneurysm and dissection (TAAD). Our team has found that a specific protein, CCN3, might be an important protector of blood vessel health. This project aims to uncover exactly how CCN3 works and its role in preventing or worsening TAAD.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding a condition that affects individuals with thoracic aortic aneurysm and dissection, including those with Marfan syndrome.
Not a fit: Patients without conditions related to vascular health or aortic aneurysms would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat thoracic aortic aneurysm and dissection by targeting the CCN3 protein.
How similar studies have performed: Preliminary studies from this lab suggest CCN3's role as an inhibitor of TAAD, indicating a novel and promising direction for further investigation.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lin, Zhiyong — Emory University
- Study coordinator: Lin, Zhiyong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.