Understanding a precancerous condition that can lead to leukemia
Official title: Clonal growth and prediction of monoclonal B-cell lymphocytosis
Funded at Mayo Clinic Rochester · NIH-11059181 · Data updated 2026-11-12
This study is looking at a condition called monoclonal B-cell lymphocytosis (MBL), which can sometimes lead to leukemia, and it aims to find a way to use genetic information to help identify people who might be at risk, so they can get earlier care and support.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 20, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $193,041 |
| NIH project number | 5R21CA282702-02 |
| Project ID | NIH-11059181 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may have monoclonal B-cell lymphocytosis or are at risk of developing it.
✕Less likely to help
Patients who do not have monoclonal B-cell lymphocytosis or related conditions may not benefit from this research.
What this research studies
This research investigates monoclonal B-cell lymphocytosis (MBL), a precancerous condition that affects millions of adults and can lead to chronic lymphocytic leukemia (CLL). The study aims to develop a method to predict MBL status using existing genetic data, which could help identify individuals at risk. By analyzing chromosomal alterations in blood samples, the research seeks to better understand the causes and consequences of MBL, particularly in diverse populations. This approach may enable earlier detection and intervention strategies for those at risk of developing more serious health issues.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and early intervention for individuals at risk of developing chronic lymphocytic leukemia and other related conditions.
How similar studies have gone: Previous research has shown promise in using genetic data to predict cancer risk, indicating that this approach may be effective.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Slager, Susan L — Mayo Clinic Rochester
- Study coordinator: Slager, Susan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.