Understanding a new type of RNA that helps cells respond to stress
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10749035
This study is looking at special molecules made by our cells when they’re under stress, like from heat or damage, to see how they help cells survive tough times, which could lead to new treatments for conditions like cancer and aging.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10749035 on ClinicalTrials.gov |
What this research studies
This research investigates a newly identified class of long non-coding RNAs (lncRNAs) that are produced in human cells when they experience stress, such as heat or oxidative damage. The project aims to sequence these RNAs to understand their structure and function, particularly how they help cells survive under challenging conditions. By using advanced sequencing techniques, the researchers will explore how these RNAs are generated and their potential roles in diseases like cancer and aging. This work could provide insights into cellular responses and lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with stress-related health conditions, including cancer patients and those experiencing age-related cellular decline.
Not a fit: Patients with non-stress-related conditions or those not experiencing cellular stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cell survival in stress-related conditions, potentially benefiting patients with cancer and age-related diseases.
How similar studies have performed: Other research has shown promising results in understanding the roles of non-coding RNAs in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEUGEBAUER, KARLA M — YALE UNIVERSITY
- Study coordinator: NEUGEBAUER, KARLA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer