Understanding a new protein's role in calcium signaling
Official title: Characterizing the Function and Regulation of Ycx1, a New Member of the CCX Family of Exchangers
Funded at Saint Louis University · NIH-10874215 · Data updated 2026-11-12
This study is looking at a new protein called Ycx1 that helps control calcium levels in our cells, which is important for keeping our bodies healthy, and it could help us understand how problems with calcium signaling might be linked to diseases like Alzheimer's.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $378,750 |
| NIH project number | 1R15GM154275-01 |
| Project ID | NIH-10874215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with conditions unrelated to calcium signaling or those not affected by Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates Ycx1, a newly discovered protein that is essential for regulating calcium ion (Ca2+) signaling in cells. By studying how Ycx1 functions, the research aims to uncover its role in controlling calcium release from cellular structures like the endoplasmic reticulum and Golgi apparatus. The project will involve biochemical experiments to assess Ycx1's activity and its impact on cellular metabolism, which is crucial for maintaining proper biological functions. This work could provide insights into how misregulation of calcium signaling contributes to diseases, including Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to calcium signaling dysregulation, such as Alzheimer's disease.
How similar studies have gone: Previous research has shown that understanding calcium signaling pathways can lead to significant advancements in treating neurodegenerative diseases, suggesting this approach has potential for success.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Wang, Yuqi — Saint Louis University
- Study coordinator: Wang, Yuqi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.