Understanding a new protein, PRR24, and its role in kidney function and blood pressure
Cloning and characterization of PRR24 as a specific renin receptor critically involved in vasopressin signaling in the kidney
This research explores a newly discovered protein in the kidney, PRR24, to understand how it helps control water balance and blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11112319 on NIH RePORTER |
What this research studies
Our kidneys play a vital role in managing the body's water and salt levels, which directly affects blood pressure. This project focuses on a recently identified protein called PRR24, located in the kidney, which appears to be a key player in this process. We are learning how PRR24 interacts with other important systems, like the renin-angiotensin system, and how it responds to hormones like vasopressin. By studying PRR24, we hope to uncover its exact role in maintaining healthy kidney function and blood pressure, as its absence in mice leads to conditions similar to diabetes insipidus.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to understand basic kidney mechanisms relevant to individuals with blood pressure issues or kidney diseases like diabetes insipidus.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to help people with conditions like high blood pressure or certain kidney disorders, such as diabetes insipidus.
How similar studies have performed: While the broader renin-angiotensin system is well-studied, the specific role of the newly identified PRR24 isoform is novel and currently being explored.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Yang, Tianxin — Utah State Higher Education System--University of Utah
- Study coordinator: Yang, Tianxin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.