Understanding a new protein modification related to viral infections
Official title: Protein Phosphoribosylation: Characterization of a novel protein modification
Funded at Beckman Research Institute/city of Hope · NIH-11119874 · Data updated 2026-11-12
This study is looking at a new way that proteins can change during herpesvirus infections to see how it affects the virus's ability to replicate, which could help us find better treatments for viral diseases.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $178,000 |
| NIH project number | 1R03DE034794-01 |
| Project ID | NIH-11119874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with herpesvirus infections or related complications.
✕Less likely to help
Patients with non-viral infections or those not affected by herpesviruses may not receive any benefit from this research.
What this research studies
This research investigates a novel protein modification called phosphoribosylation, particularly in the context of herpesvirus infections. By studying how this modification affects viral replication and the behavior of key proteins, the research aims to uncover new insights into the mechanisms of viral infections. The approach involves examining the role of specific enzymes and proteins during the infection process, which could lead to a better understanding of how viruses manipulate host cellular machinery. Patients may benefit from findings that could inform new therapeutic strategies against viral diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for viral infections, particularly those caused by herpesviruses.
How similar studies have gone: While the specific focus on phosphoribosylation in the context of viral infections is relatively novel, similar research on post-translational modifications has shown promise in understanding disease mechanisms.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Feng, Shu — Beckman Research Institute/city of Hope
- Study coordinator: Feng, Shu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.