Understanding a New Genetic Factor in Preeclampsia
Novel NF-kB variant in preeclampsia
This research looks at a new genetic factor that might contribute to preeclampsia, a serious condition affecting pregnant women.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11145935 on NIH RePORTER |
What this research studies
Preeclampsia is a serious pregnancy complication that affects many women and infants each year, often due to problems with the placenta and blood flow. This project focuses on a specific genetic difference, called an NF-kB variant, that researchers recently found to be linked with preeclampsia. We want to understand how this genetic difference affects the body's inflammatory responses and blood vessel function during pregnancy. By studying pregnant women, especially those living at high altitudes where preeclampsia is more common, we hope to learn more about why this condition develops.
Who could benefit from this research
Good fit: This research focuses on pregnant women, particularly those in high-altitude populations, who are affected by or at risk for preeclampsia.
Not a fit: Patients not currently pregnant or those without preeclampsia would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to identify women at risk for preeclampsia and develop new treatments to prevent or manage it.
How similar studies have performed: While the specific genetic variant is novel, the role of inflammation and genetic factors in preeclampsia has been explored in other studies.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Julian, Colleen Glyde — University of Colorado Denver
- Study coordinator: Julian, Colleen Glyde
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.