Understanding a new cellular network that helps bone regeneration in the face.
Official title: Characterization and function of a new p75-NTR+ cellular network in craniofacial bone
Funded at Washington University · NIH-10571278 · Data updated 2026-11-12
This study is looking at special cells that help heal bones in the face, and it aims to understand how these cells work so we can find new ways to help bones heal better in other parts of the body too.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $427,625 |
| NIH project number | 1R21DE032420-01 |
| Project ID | NIH-10571278 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with craniofacial bone injuries or conditions that require enhanced bone regeneration.
✕Less likely to help
Patients with non-craniofacial bone issues or those who do not require bone regeneration may not benefit from this research.
What this research studies
This research investigates a newly identified network of cells that express the p75 neurotrophin receptor, which plays a crucial role in the regeneration of craniofacial bone. The study aims to uncover how these cells contribute to the healing process and whether their regenerative capabilities can be replicated in other skeletal areas. By examining the mechanisms behind this cellular network, researchers hope to develop innovative strategies to enhance bone healing and regeneration. The approach involves advanced cell culture techniques and analysis of gene expression related to bone growth.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve bone healing and regeneration for patients with craniofacial injuries or conditions.
How similar studies have gone: Previous research has shown promising results in understanding cellular mechanisms for bone regeneration, but this specific approach is novel and untested.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Scheller, Erica Lynn — Washington University
- Study coordinator: Scheller, Erica Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.