Understanding a natural signal that helps control body weight and energy
Role of a lactate-derived signaling metabolite in tissue crosstalk and energy balance
This project explores how a natural signal in the body, made from lactate, helps manage energy and body weight, which could be important for conditions like adult-onset diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11124201 on NIH RePORTER |
What this research studies
Our bodies produce a molecule called Lac-Phe from lactate, which acts as a signal between different tissues to help control how we use energy and manage our appetite. This research aims to understand the detailed biochemical steps involved in making Lac-Phe and how it communicates within the body. We are particularly interested in its role in suppressing hunger and preventing obesity. This work builds on recent discoveries, suggesting that Lac-Phe is a key player in maintaining a healthy energy balance.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but aims to understand biological processes relevant to individuals with adult-onset diabetes or obesity.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this work could lead to new ways to help manage body weight and energy balance, potentially offering new strategies for adult-onset diabetes.
How similar studies have performed: This research builds on recent discoveries by the same team about Lac-Phe's role in energy balance, suggesting a novel and promising area of investigation.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Long, Jonathan Z — Stanford University
- Study coordinator: Long, Jonathan Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.