Understanding a Liver Protein that Manages Body Energy
A liver-specific mitochondrial carrier that controls energy homeostasis
This work explores a special protein in the liver that helps control how our bodies use energy, which could lead to new ways to help people with metabolic conditions like high blood sugar and obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11142980 on NIH RePORTER |
What this research studies
Our bodies rely on tiny powerhouses called mitochondria to supply energy and other important materials to our cells. A specific protein in the liver, called SLC25A47, acts like a gatekeeper, controlling what goes in and out of these powerhouses. We are learning how this protein works and if blocking its activity could help reduce high blood sugar and obesity. This could offer a new way to manage metabolic diseases by targeting the liver.
Who could benefit from this research
Good fit: This foundational work is relevant for individuals living with or at risk for metabolic diseases, including hyperglycemia and obesity.
Not a fit: Patients without metabolic conditions or those whose conditions are not related to liver energy regulation may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically target the liver to help manage high blood sugar and obesity.
How similar studies have performed: While the specific carrier SLC25A47 is newly identified and unique, the broader concept of targeting mitochondrial carriers for metabolic health has been explored in other contexts.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Kajimura, Shingo — Beth Israel Deaconess Medical Center
- Study coordinator: Kajimura, Shingo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.