Understanding a key signaling pathway in acute myeloid leukemia
Elucidating the SCP4 pathway as a multi-catalytic signaling dependency in acute myeloid leukemia
This study is looking at a specific pathway in leukemia cells to understand how it helps them survive, with the hope of finding new treatments that can better target leukemia without harming healthy cells, which could lead to better options for patients with acute myeloid leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-10897025 on NIH RePORTER |
What this research studies
This research investigates the SCP4 pathway, which is crucial for the survival of acute myeloid leukemia (AML) cells. By using advanced techniques like CRISPR screening, the researchers aim to uncover how SCP4 interacts with other proteins to support AML growth. The study will explore the genetic and biochemical mechanisms behind this pathway, potentially leading to new therapeutic strategies that specifically target AML while sparing normal cells. Patients may benefit from insights gained that could lead to more effective treatments for AML.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia.
Not a fit: Patients with other types of leukemia or those without a diagnosis of acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in other cancers, suggesting potential for success in this novel approach.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Vakoc, Christopher — Cold Spring Harbor Laboratory
- Study coordinator: Vakoc, Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.